On April 4, 2024, the U.S. Centers for Disease Control and Prevention (CDC) updated the Biosafety Laboratory Guidance for Handling and Processing Mpox Specimens webpage to include information about clade I and to clarify select agent requirements. CDC also updated the How to Report Results from Orthopoxvirus, Non-Variola Orthopoxvirus, and Mpox Virus Diagnostic Testing webpage to reflect the preferred names and identification of the clades.